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- Cheat mode
Use a text editor such as Notepad to edit the "defuser.ini" file in the game directory. Set a key binding to the following codes (for example, "F10=fly". Then, press the corresponding key during game play to activate the corresponding cheat function. Note: Any active codes are disabled when a new area loads or intermission sequence plays.
Effect - Code
God mode - god
Disable clipping - ghost
Flight mode - fly
Disable fly and ghost codes - walk
Teleport to pointer - teleport
- Defeating Atlas Fontaine
This is the final Boss and he has three different styles of attacks:. Flame Plasmid Form, Ice Plasmid Form, and Electric Plasmid Form. The easiest way to defeat him in the first part is to use your Ice Plasmid and freeze him. Then, switch to your Telekinesis Plasmid. Grab an explosive tank and throw it at him. Also, if desired, just use your telekinesis. He is very predictable if you are far away from him. Wait for him to throw a fire ball at you then move out of the way. He will continue to run past you. Use this chance to fire the machine gun, which does the most damage to him. Once he goes back to his chamber to gain his life back, change to the Flame Plasmid and get ready for some bots. Once he starts his routine of fire and run, blast again him with the Flame Plasmid . The more you blast him, the faster he loses life. Continue to use the machine gun while he is aflame. He will now go back to his chamber one last time. He now has electrical powers. Keep your Flame Plasmid ready. This time, shoot him with the Flame Plasmid and he will run for the water. Once he jumps in the water and comes back out, hit him with it again. Be aware that there are splicers all over as well. Also set them ablaze to get some extra life. There are many different ways to defeat him but this seemed to be the easiest.
- Defeating Peach Wilkins
When the dark cloud envelopes the icy battlefield upon which you must face Peach Wilkins, save the game and locate the hostile turret at the end of the room when the cloud clears. Load the game and run to it before the cloud clears, so that you can quickly freeze or shock it. Then, hack it so it shoots your enemies. Crouch down by the area to your right when facing the turret. There are a few barriers here to protect you from enemy fire. However, to avoid damage by Wilkins' grenades, keep Telekinesis as your active Plasmid. He will avoid the turret's fire, but as long as you stay behind the barriers by the turret he will stay at a safe distance. This gives you time to calmly return his grenades using Telekinesis until he dies. The turret will take out most of the Splicers. This method makes things much easier because it eliminates the hectic "run around and whack people with the wrench" strategy that is otherwise your only option. That turret if not used as an ally would probably be the main cause of your death, along with the bots triggered by the security camera. By hiding near the allied turret however, you also hide from the camera's view.
- Defeating Rosies
When fighting a Rosie, use armor piercing rounds from the machine gun or pistol. For a more effective way of killing, launch frag grenades and run out a door. The Rosie will follow you, fire proximity mines at the door, and when it walks through it will be damaged or destroyed.
- Defeating security robots
If you are up against a stationary security robot (RPG, etc.), use Telekenesis to grab a crate or pallet. Hold it in front of you until you can find a place to hide and plan what to do next. The item you hold up will block some attacks.
- Defeating: Frank Fontaine
To defeat Frank Fontaine very fast, when you first enter the room hit him with the tool the Little Sisters gave you. Fight him when he throws you off. Once he is back on the bed, run up and hit him again with the tool to drain his Adam. This works a lot faster due to him only have four or five jars of Adam to drain, and the fights are not very long afterwards.
- Easy kills
From the start you will have a wrench and the Electric Bolt Plasmid at your disposal. Using these is rapid succession against most Splicers can often result in an efficient, quick kill. First, shock the Splicer. Before the convulsion ends, switch out the wrench, aim high, and hit the Splicer over the head. The most efficient way of eliminating the agile Spider Splicers however is to unleash a few clips of anti-personnel ammo, preferably from the machine gun.
- Easy Splicer Kills
Simply use Telekinesis on one to hurl a body at others. This method usually results in a one-hit kill and is especially useful against higher-level Splicers.