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- A3-21's Plasma Rifle
This is a special plasma rifle. It can be obtained from Harkness after siding with him in the "Replicated Man" quest. It can be repaired with regular plasma rifles, but degrades slowly. Its damage is 50.
- Abraham Lincoln shrine in Arlington Cemetery North
The house with the Luck bobblehead also contains a hidden shrine to Abraham Lincoln.
- Alien and alien blaster
Go to the Minefield then head north if you keep going you'll eventually pick up a radio signal from the alien space craft when you find it there is a space craft and special gun with limited ammo.
- Alien Blaster
This is a special weapon. It can be obtained from the body of a dead alien lying a few feet away from its crashed spaceship. The alien crash site is found north of MDPL-13 Power Station and northwest of the Greener Pastures Disposal Site. It has unique ammunition as well, the Alien Power Cell, which is exceedingly rare. The chance of a critical strike with this gun is nearly 100%. It can be repaired with the Firelance, but degrades incredibly quickly. Its damage is 100.
- Blackhawk
This is a special scoped .44 Magnum. The Blackhawk is obtained from Agatha in the "Agatha's Song" quest in return for the Sheet Music book. You must ask for a reward. There is a higher chance of the weapon being in good condition if you speak politely to Agatha throughout the quest. It can be repaired with regular scoped .44 Magnums. Its damage is 55.
- Blade Runner reference
The .233 pistol's design is a reference to the pistol carried by Harrison Ford's character, Rick Deckard, in the movie Blade Runner.
- Bobblehead locations
Collect the following hidden bobbleheads to gain +10 to a skill or +1 to a stat.
Stats
Strength: Megaton, in Sherriff Lucas Simm's house.
Perception: Republic Of Dave, on a bookshelf on the right in the Museum of Dave.
Endurance: Deathclaw Sanctuary, at the entrance on a table next to a rotting Brahmin corpse.
Charisma: Vault 108, in the Cloning Lab.
Intelligence: Rivet City, on Dr. Li's table in the Science Lab.
Agility: Greener Pastures Disposal, in the small office covered in radiation.
Luck: Arlington Cemetery North, in the basement on a shelf directly below the stairs inside the house to the north.
Skills
Barter: Evergreen Mills, in back of the Market Bazaar on a shelf in the upper-right side behind the Raider Trader that does not attack.
Big Guns: Fort Constantine, in the basement of the CO Quarters inside a safe in the wall.
Energy Weapons: Ravenhold
Explosives: WKML Broadcast Station, turn on your local map. Go through the doorway to the sealed cistern and find it.
Lockpick: Bethesda Ruins, in Bethesda Offices East on the top floor near the door to the bridge.
Medicine: Vault 101, on your dad's desk when leaving.
Melee Weapons: Dunwich Building, just before you leave the Virulent Underchambers, on the floor next to the door.
Repair: Aerefu, in Evan King's house.
Science: Vault 106, on a table in middle of the living quarters second level main room.
Small Guns: National Guard Depot, go through the training room and offices to exit from a door to the main room. Use the power switch on the wall to your left and enter the Armory door, then search the shelves.
Sneak: Yao Guai Tunnels, on top of a metal box in the Den, on the right of the map near some water.
Speech: Paradise Falls, on a table inside Euology's pad (Slave Master's house).
Unarmed: Rockopolis, go directly west from Casey Smith's garage. Look for tattered banners that are strung up. Use your local map to find it.
- Boosting Your Experience
Here’s a great (albeit cheap) way to gain lots of experience. Before you do anything that’s going to net you some experience (such as picking locks, hacking, et cetera), change the game’s difficulty setting to Very Hard. Then, hack the computer or pick the lock (or whatever). Successfully doing so on a harder difficulty level will get you more experience. You can also utilize this technique on mortally-wounded enemies to gain more experience from them as well. Just be sure to change the difficulty back to a more manageable level when you’re done!