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- Big Daddy Battle
In order to do this, you need the Hypnotize Big Daddy Plasmid and the Natural Camouflage Tonic. All you have to do is use the Hypnotize Big Daddy Plasmid on a Big Daddy so that he thinks you're a Little Sister and protects you. Now here's the fun part - simply find and attack another Big Daddy and your Big Daddy will attack it to protect you.
- Big Daddy Kills
When fighting a Big Daddy, use armor-piercing rounds, as they will deal considerable damage compared to regular rounds.
- Big Daddy Kills II
Once you get the Grenade Launcher and the Proximity Mines, this technique can be employed. Find a red fuel tank (all over the place), and cover it with about 6 Proximity Mines or so. Next, use Telekinesis to lift the massive explosive device and hurl it at a Big Daddy. This deals massive damage, leaving you with minimal effort to finish the job. Just be careful not to have the bomb blow up before you get there. (The launcher upgrade that deals no damage to you is a great thing to have just in case.)
- Big Daddy Kills III
Here's another technique to take out Big Daddies. Use the Electric Buck on your Shotgun, alternating between the buck and using the Electro Bolt Plasmid every few seconds (which will shock and freeze him in addition to dealing damage). This technique is especially useful on Bouncer class Big Daddies.
- Big Daddy Kills IV
Once you've obtained the Dart Gun, you can try this technique. All that's required is Electrical Trap Darts (4-6 per Big Daddy). Take your 4-6 Trap Darts and line them down a hall or near where you can see a Big Daddy, making sure the path he'll take towards you is amply covered. Once that's done, shoot at the Big Daddy to get his attention and keep him running towards you. He'll run into each dart and kill himself.
- Big Daddy Kills V
If you have Trap Bolts for your Crossbow, you can execute this technique to kill Big Daddies easily. Give yourself about 20 feet (in-game, of course) and shoot your Trap Bolts so they hang between you and the location of the Big Daddy you want to kill. Then shoot a round with another weapon at the Big Daddy to anger it so it comes towards you. It will stumble across the Trap Bolts you've shot and die, since it only takes two of them to take one down.
- Big Daddy Kills VI
Here's another easy method to kill Big Daddies easily. Try using Electric Gel in the Chemical Thrower. It takes about 3/4 of a tank, but the Big Daddy won't be able to move as you shoot and kill him.