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- Alternate endings
There are six alternate endings: rise to surface (good and evil), abandoned (good and evil), and the standard ending (good and evil).
Good endings Rescue all Little Sisters that you dealt with and spare Grace Holloway, Stanley Poole, or Gilbert Alexander.
Good endings Rescue all Little Sisters That you dealt with and kill Grace Holloway, Stanley Poole, and Gilbert Alexander.
Standard endings Rescue at least one Little Sister and harvest at least one Little Sister. Choose to die at the end and spare Grace Holloway, Stanley Poole, and Gilbert Alexander.
Standard endings Rescue at least one Little Sister and harvest at least one Little Sister. Choose to die at the end and kill Grace Holloway, Stanley Poole, or Gilbert Alexander.
Bad endings Rescue at least one Little Sister and harvest at least one Little Sister. Choose to live at the end and spare Grace Holloway, Stanley Poole, and Gilbert Alexander. Alternately, harvest all Little Sisters that you dealt with and spare Grace Holloway, Stanley Poole, and Gilbert Alexander.
Bad endings Rescue at least one Little Sister and harvest at least one Little Sister. Choose to live at the end and kill Grace Holloway, Stanley Poole, or Gilbert Alexander. Alternately, harvest all Little Sisters that you dealt with and kill Grace Holloway, Stanley Poole, or Gilbert Alexander.
- Defeating Big Sisters
Before you fight the second Big Sister (if you are harvesting ADAM but saving the girls), you will get an Enrage Plasmid. There are two bodies to scrounge ADAM from. One is more easily securable, which has a security camera, a rocket launcher bot, and a large puddle of water in this area. The Big Daddy comes back multiple times. If you drop off the little girl in her hole near here, you can wait for the Big Sister to show up. Then, enrage the Big Daddy so that he will take on and kill the Big Sister. Your only concern will be Splicers and the Big Daddy after he is done with the Big Sister.
- Defeating Rumblers
When facing a Rumbler (Big Daddy with rockets) use Telekinesis to grab the rockets it fires then turn them back towards it.