During the part where Snake is locked up in a jail cell, access your radio and set the frequency to 144.75. Doing so automatically unlocks the cell door.
During the cutscene in Granin's office, use the camera to pan around the room. You'll find figurines of Metal Gear REX, Metal Gear RAY, and Jehuty, which are from the previous Metal Gear Solid and Zone of the Enders games respectively.
After walking through the cave and the river at Ponizovje, you'll see a cutscene. As soon as the cutscene ends, equip your SVD sniper rifle and aim it at The End. If you shoot quickly and accurately enough, you can kill The End and skip his boss battle later on. There will be a platoon of soldiers to fight instead.
Some weapons, such as the RPG-7, take a long time to reload. To skip the extra reloading animations, just equip another weapon, and then immediately switch back.
During the battle with The Sorrow, immediately lie down in the water. You'll eventually drown, thus prompting the Game Over screen. Instead of choosing the usual options, use the Revival Pill in your inventory; doing so skips the entire fight and allows you to continue the mission.
Once you get the Single Action Army, you can twirl it by moving the 3DS system while in FPS aiming mode. This allows you to show off Snake's skill with a revolver and distract Ocelot during your duel with him at Bolshaya Past Crevice. When you're in the open, twirl your revolver and Ocelot will respond with his own revolver tricks and commentary.
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